张磊

发布时间:2023-07-25录入员:



姓名:张磊

职称:教授

个人简介:安徽安庆人,教授,博导,南通大学特聘教授,海军军医大学药学院药用植物学教研室主任;国家杰出青年科学基金获得者,青年长江学者、国家首届青年岐黄学者军队高层次科技创新人才学科拔尖人才、上海市优秀学术带头人浦江人才青年科技启明星巴渝学者讲座教授、享受国务院政府特殊津贴。中华中医药学会青委会副主委,世中联中药分析专委会常务理事,全军药学会中药与天然药物专委会常委,秘书;上海市植物生理与植物分子生物学学会副理事长,上海市上海市植物学会植物生物技术专委会主任委员,Medicinal Plant Biology副主编,《药学学报》、《中草药》、APSBCJNM等期刊编委或青年编委。主要从事中药资源保障与质量提升研究。先后主持国家自然科学基金杰青、重点项目、面上项目、重点研发计划子课题等多项国家级项目。在 Nat Chem. BiolNat CommunTrends Plant SciPNASMol PlantSci BullNew PhytolPlant Biotechnol JAPSBJIPB等期刊发表SCI论文160余篇。获9项专利授权。获教育部科技进步奖一等奖和明治乳业生命科学奖。

专业研究领域:

生药学,围绕中药资源保障与质量提升重大战略需求:以阐明中药有效成分形成机制为起点,构建多组学驱动的天然产物合成关键酶系发掘及机理解析技术体系,高通量挖掘药用植物基因资源,克隆鉴定未知功能基因,解析新颖代谢途径;以调控中药有效成分生物合成为重点,开展预见性代谢工程,为定向调控和定量合成目标产物提供成功范例;以优质药材可持续供应为落脚点,基于分子智能设计育种创制 “高产、高抗、高涵理想药用植物,加速优异种质创新进程;构建优化微生物细胞工厂,实现活性天然产物异源高效合成和中药资源强劲灵活供应。

代表性专著与论集:

1)       Yun Wang#, Luyao Yu#, Jie Shao#, Zhanpin Zhu#, Lei Zhang*. Structure-driven Protein Engineering for Production of Valuable Natural Products. Trends in Plant Science, 2023, 28: 460-470. (IF=20.5, 中科院一区)

2)       Zhiying Guo#, Kai Hao#, Zongyou Lv#, Luyao Yu, Qitao Bu, Junze Ren, Henan Zhang*, Ruibing Chen*, Lei Zhang*. Profiling of phytohormone-specific microRNAs and characterization of the miR160-ARF module involved in glandular trichome development and artemisinin biosynthesis in Artemisia annua. Plant Biotechnology Journal, 2023, 21: 591-605. (IF=13.8, 中科院一区)

3)       Ruibing Chen, Jiaoqi Gao, Wei Yu, Xianghui Chen, Xiaoxin Zhai, Yu Chen, Lei Zhang*, Yongjin J. Zhou*. Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast, Nature Chemical Biology, 2022, 18: 520-529. (IF=14.8, 中科院一区)

4)       Ruibing Chen#, Yuejuan Bu#, Junze Ren, Kyle A. Pelot, Xiangyang Hu, Yong Diao, Wansheng Chen, Philipp Zerbe, Lei Zhang*. Discovery and modulation of diterpenoid metabolism improves glandular trichome formation, artemisinin production and stress resilience in Artemisia annua, New Phytologist, 2021, 230(6): 2387-2403. (IF=9.4, 中科院一区)

5)       Ying Xiao#, Kai Shao#, Jingwen Zhou#, Lian Wang, Xueqi Ma, Di Wu, Yingbo Yang, Junfeng Chen, Jingxian Feng, Shi Qiu, Zongyou Lv, Lei Zhang*, Peng Zhang*, Wansheng Chen*. Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases. Nature Communications, 2021, 12(1): 2828-2838. (IF=16.6, 中科院一区)

6)       Zongyou Lv#, JinXing Li#, Shi Qiu, Fei Qi, Hang Su, Qitao Bu, Rui Jiang, Kexuan Tang*, Lei Zhang*, Wansheng Chen*. The transcription factors TLR1 and TLR2 negatively regulate trichome density and artemisinin levels in Artemisia annua. Journal of Integrative Plant Biology, 2022, 64(6), 1212-1228. (IF=11.4, 中科院一区)

7)       Hexin Tan#, Ling Xiao#, Shouhong Gao, Qing Li, Junfeng Chen, Ying Xiao, Qian Ji, Ruibing Chen, Wansheng Chen, Lei Zhang*. TRICHOME AND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua. Molecular Plant, 2015, 8(9), 1396-1411. (IF=27.5, 中科院一区)

8)       Ying Xiao#, Jingxian Feng#, Qing Li, Yangyun Zhou, Qitao Bu, Junhui Zhou, Hexin Tan, Yingbo Yang, Lei Zhang*, Wansheng Chen*. IiWRKY34 positively regulates yield, lignan biosynthesis and stress tolerance in Isatis indigotica. Acta Pharmaceutica Sinica B, 2020, 10(12), 2417-2432. (IF=14.5, 中科院一区)

9)       Lei Zhang#, Junfeng Chen#, Xun Zhou#, Xiaofei Chen, Qing Li, Hexin Tan, Xin Dong, Ying Xiao, Langdong Chen, Wansheng Chen*. Dynamic metabolic and transcriptomic profiling of methyl jasmonate-treated hairy roots reveals synthetic characters and regulators of lignan biosynthesis in Isatis indigotica Fort. Plant Biotechnology Journal, 2016, 14(12), 2217-2227. (IF=13.8, 中科院一区)

10)    Zongyou Lv, Zhiying Guo, Lida Zhang, Fangyuan Zhang, Weimin Jiang, Qian Shen, Xueqing Fu, Tingxiang Yan, Pu Shi, Xiaolong Hao, Yanan Ma, Minghui Chen, Ling Li, Lei Zhang*, Wansheng Chen*, Kexuan Tang*. Interaction of bZIP transcription factor TGA6 with salicylic acid signaling modulates artemisinin biosynthesis in Artemisia annua. Journal of Experimental Botany, 2019, 70(15), 3969-3979. (IF=6.9, 中科院一区)

11)    Hexin Tan#*, Xianghui Chen#, Nan Liang#, Ruibing Chen#, Junfeng Chen, Chaoyang Hu, Qi Li, Qing Li, Weizhong Pei, Wenhai Xiao, Yingjin Yuan, Wansheng Chen, Lei Zhang*. Transcriptome analysis reveals novel enzymes for apo-carotenoid biosynthesis in saffron and allows construction of a pathway for crocetin synthesis in yeast. Journal of Experimental Botany, 2019, 70(18), 4819-4834. (IF=6.9, 中科院一区)

12)    Ying Xiao, Qian Ji, Shouhong Gao, Hexin Tan, Ruibing Chen, Qing Li, Junfeng Chen, Yingbo Yang, Lei Zhang*, Zhengtao Wang*, Wansheng Chen*, Zhibi Hu. Combined transcriptome and metabolite profiling reveals that IiPLR1 plays an important role in lariciresinol accumulation in Isatis indigotica. Journal of Experimental Botany, 2015, 66(20), 6259-6271. (IF=6.9, 中科院一区)

代表性发明专利

1)       张磊,刁勇,郭志英,谭何新,黄豆豆,陈越,一种马蓝BcTSA基因及其编码的蛋白与应用,专利号:201910133567.9,授权日期:2022311

2)       卜其涛,张磊,陈万生,吕宗友,一种用RNA干扰提高青蒿中青蒿素含量的方法,专利号:ZL202011245060.1,授权日期:2022816

3)       陈万生,张磊,陈亮,李卿,冯婧娴,王芸,谭何新,陈昊轩,提高丹参毛状根中丹酚酸B含量的方法与漆酶基因,专利号:ZL201710447660.8,授权日期:20201201

4)       马瑞芳,张磊,陈万生,肖莹,菘蓝IiAP2/ERF049基因在调控木脂素类化合物合成中的应用,专利号:ZL201610502516.5,授权日期:20190806

5)       张磊,吴循循,陈啸飞,刁勇,全面筛选青黛中抗白血病活性成分及确定其靶标的方法,专利号:ZL201511021978.7,授权日期:20181120

6)       季倩,张磊一种快速提高丹参中迷迭香酸含量的方法,专利号:ZL201410606226.6,授权日期:20180605

7)       谭何新,张磊,肖玲,青蒿AaGTD1基因及其编码的蛋白与应用,专利号:ZL201510054313.X,授权日期:20180209

人才称号:

1)       国家杰出青年科学基金(2022

2)       国家中医药首届青年岐黄学者2021

3)       教育部青年长江学者2016

4)       军队高层次科技创新人才学科拔尖人才2022

5)       巴渝学者讲座教授(2022

6)       上海市优秀学术带头人2019

7)       上海市浦江人才2014

8)       上海市青年科技启明星2006

荣誉奖励:

1)       教育部科技进步一等奖(2016,第二完成人)

2)       上海市优秀博士学位论文(2008

3)       第九届明治生命科学奖2006

4)       联合利华(Unilever科研奖学金(2006

5)       全军优秀硕士学位论文(2004

指导研究生情况:

已毕业博士生3名,已毕业硕士生8名,在读博士生4名,在读硕士生7名。指导研究生两人次分别入选全军和上海市优秀硕士学位论文。